https://projectreporter.nih.gov/project_info_description.cfm?aid=9930079&icde=51360866
Deregulation of Long Noncoding RNA in the Pathogenesis of Autosomal Dominant Polycystic Kidney Disease
Preventing the formation or slowing the growth of kidney cysts is crucial to the long-term survival and quality of life of patients with polycystic kidney disease (PKD). The proposed research is broadly relevant to public health because it will be the first study to identify a lncRNA (Hoxb3os) that directly binds to and inhibits mTORC1 activity. Results from this study will provide genetic proof-of-concept for future studies that focus on targeting lncRNAs as a treatment option in PKD.