This page tracks new and upcoming treatment options for autosomal dominant polycystic kidney disease (ADPKD). What’s in development? What’s promising? What’s available soon? Current topics include RGLS4326, XRx-008, gene therapy, LoAc, PDE4 activators, venglustat, and more. Jump to section: News, Research, Clinical Trials
Last updated: 5 years ago
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News
- Palladio Completes $20 Million Series B Financing: Proceeds will support development of lixivaptan, a potential treatment for ADPKD Sep 25, 2020
- Reproducing the pathophysiology of polycystic kidney disease from human iPS cells: Understanding the pathogenesis of ADPKD and developing new treatments Aug 21, 2020
- An affordable and commonly used diabetes drug is being touted as a potential treatment for ADPKD Jul 30, 2020
- FDA has granted Regulus Therapeutics orphan drug designation for RGLS4326, an investigational therapy being studied to treat ADPKD Jul 29, 2020
- XORTX Provides Overview and Update of Key Activities – Including Update on XRx-008 for Autosomal Dominant Polycystic Kidney Disease (ADPKD) Apr 30, 2020
- PKD Foundation Receives $9.3 Million Donation – 100 percent of gift is designated to research and finding a cure for PKD Jan 20, 2020
- Promising new drug being developed for polycystic kidney disease Sep 12, 2019
- XORTX Highlights New Research on Polycystic Kidney Disease Awareness Day Sep 4, 2019
- KC charity will invest $5M to fund research into a cure for PKD Jun 25, 2019
- New drug compound could tackle major life-limiting kidney disease (ADPKD) Jun 18, 2019
Research
- Salt, water, and vasopressin in polycystic kidney disease Oct 1, 2020
- Genetics May Predict Effectiveness of Tolvaptan in Autosomal Dominant Polycystic Kidney Disease Aug 12, 2020
- A novel ADPKD model using kidney organoids derived from disease-specific human iPSCs Aug 4, 2020
- Implications of early diagnosis of autosomal dominant polycystic kidney disease Mar 9, 2020
- A high-throughput screening platform for Polycystic Kidney Disease (PKD) drug repurposing utilizing murine and human ADPKD cells Mar 6, 2020
- Quest for the Cure: Testing the Old and New to Prevent Progression of Autosomal Dominant Polycystic Kidney Disease Oct 31, 2019
- Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease Sep 12, 2019
- Caffeine Accelerates Cystic Kidney Disease in a Pkd1-Deficient Mouse Model Apr 13, 2019
Clinical Trials
- Metformin as a Novel Therapy for Autosomal Dominant Polycystic Kidney Disease Sep 15, 2020
- A Medical Research Study Designed to Determine if Venglustat Can be a Future Treatment for ADPKD Patients Sep 14, 2020
- A Trial of Bardoxolone Methyl in Patients With ADPKD – FALCON (FALCON) Aug 6, 2020
- Efficacy and Safety of Lixivaptan in the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD) Jul 29, 2020
- Safety, Pharmacokinetics, Tolerability and Efficacy of Tolvaptan in Children and Adolescents With ADPKD (Autosomal Dominant Polycystic Kidney Disease) May 15, 2020
- Study of the Efficacy and Safety of Tesevatinib in Subjects With ADPKD Mar 16, 2020
- Pravastatin and Alkali Therapy in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD-SAT) Feb 26, 2020