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ADPKD Treatment Report

www.ADPKDTreatmentReport.com

This page tracks new and upcoming treatment options for autosomal dominant polycystic kidney disease (ADPKD). What’s in development? What’s promising? What’s available soon? Current topics include RGLS4326, XRx-008, gene therapy, LoAc, PDE4 activators, venglustat, and more. Jump to section: News, Research, Clinical Trials

Last updated: 5 years ago
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News

  • Palladio Completes $20 Million Series B Financing: Proceeds will support development of lixivaptan, a potential treatment for ADPKD Sep 25, 2020
  • Reproducing the pathophysiology of polycystic kidney disease from human iPS cells: Understanding the pathogenesis of ADPKD and developing new treatments Aug 21, 2020
  • An affordable and commonly used diabetes drug is being touted as a potential treatment for ADPKD Jul 30, 2020
  • FDA has granted Regulus Therapeutics orphan drug designation for RGLS4326, an investigational therapy being studied to treat ADPKD Jul 29, 2020
  • XORTX Provides Overview and Update of Key Activities – Including Update on XRx-008 for Autosomal Dominant Polycystic Kidney Disease (ADPKD) Apr 30, 2020
  • PKD Foundation Receives $9.3 Million Donation – 100 percent of gift is designated to research and finding a cure for PKD Jan 20, 2020
  • Promising new drug being developed for polycystic kidney disease Sep 12, 2019
  • XORTX Highlights New Research on Polycystic Kidney Disease Awareness Day Sep 4, 2019
  • KC charity will invest $5M to fund research into a cure for PKD Jun 25, 2019
  • New drug compound could tackle major life-limiting kidney disease (ADPKD) Jun 18, 2019

Research

  • Salt, water, and vasopressin in polycystic kidney disease Oct 1, 2020
  • Genetics May Predict Effectiveness of Tolvaptan in Autosomal Dominant Polycystic Kidney Disease Aug 12, 2020
  • A novel ADPKD model using kidney organoids derived from disease-specific human iPSCs Aug 4, 2020
  • Implications of early diagnosis of autosomal dominant polycystic kidney disease Mar 9, 2020
  • A high-throughput screening platform for Polycystic Kidney Disease (PKD) drug repurposing utilizing murine and human ADPKD cells Mar 6, 2020
  • Quest for the Cure: Testing the Old and New to Prevent Progression of Autosomal Dominant Polycystic Kidney Disease Oct 31, 2019
  • Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease Sep 12, 2019
  • Caffeine Accelerates Cystic Kidney Disease in a Pkd1-Deficient Mouse Model Apr 13, 2019

Clinical Trials

  • Metformin as a Novel Therapy for Autosomal Dominant Polycystic Kidney Disease Sep 15, 2020
  • A Medical Research Study Designed to Determine if Venglustat Can be a Future Treatment for ADPKD Patients Sep 14, 2020
  • A Trial of Bardoxolone Methyl in Patients With ADPKD – FALCON (FALCON) Aug 6, 2020
  • Efficacy and Safety of Lixivaptan in the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD) Jul 29, 2020
  • Safety, Pharmacokinetics, Tolerability and Efficacy of Tolvaptan in Children and Adolescents With ADPKD (Autosomal Dominant Polycystic Kidney Disease) May 15, 2020
  • Study of the Efficacy and Safety of Tesevatinib in Subjects With ADPKD Mar 16, 2020
  • Pravastatin and Alkali Therapy in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD-SAT) Feb 26, 2020

Projects

  • Deregulation of Long Noncoding RNA in the Pathogenesis of Autosomal Dominant Polycystic Kidney Disease Apr 1, 2020

Discussion

  • ADPKD: Polycystic Kidney Disease – Reddit

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